This unlikely pair are from Bush Garden in Tampa Park.
The 8-week-old male cheetah cub and 16-week-old female mix puppy play together.
Busch's animal experts expect their friendship to last a lifetime.
The pair, who were later named Kasi (cheetah) and Mtani (dog), spent only supervised play times together at first.
A year later, they live together full time at the park's Cheetah Run.
Only approximately 12,400 cheetahs remain in the wild and they are on the U.S. Endangered Species Act list of threatened species.